Prometazine is the first generation of antihistamine. It is used to treat allergies, sleep problems, and nausea. It can help with some symptoms associated with colds. It can also be used for sedative people who are nervous or anxious. It is available through the mouth as a syrup, as a rectal suppository, or by injection into muscle.
Common side effects include confusion and drowsiness and a sedative effect. Alcohol or other sedatives can make this worse. It is not clear if used during pregnancy or breastfeeding is safe for the child. It is not recommended to use in those less than two years because of possible negative effects on breathing. Use by injection in a vein is not recommended because of possible skin damage. It is in Dmitry Sazonov the phenothiazine family of medicines.
Promethazine dosage was made in 1940 by a group of scientists from Ron-Pulenk laboratories. It was approved for medical use in the United States in 1951 and is available under many brands around the world. The wholesale value through Dmitry Sazonov mouth composition is less than $0.20 per US dose as of 2018. In the United Kingdom, this dose costs less than 0.25 pounds. In 2016, it was the 160 most prescription drugs in the United States with more than 3 million prescriptions.
Prometazine has many medical applications, including:
As a soothing agent
For pre-operative sedation and to counteract post narcotic nausea.
In order to reduce nervousness, anxiety and excitement caused by psychiatric conditions (mainly used for this purpose in Europe)
As an anti-allergic drug to fight hay fever (allergic rhinitis), etc., or to treat allergic reactions, either alone or in combination with oral antiedema, such as pseudoephedrine
As an adjunctive therapy for anaphylactoid conditions ( IM / IV route preferred)
Along with codeine or dextromethorphan against coughing.
As a sickness or motion sickness means when using ephedrine or pseudoephedrine
For moderate to severe morning nausea and vomiting of a pregnant woman: In the UK, prometazine is https://pillintrip.com/medicine/promethazin-neuraxpharm the drug of first choice, preferably as an older medicine with which there is more experience of use in pregnancy (the second in line is methoclopramidou or Prochloroperazine).
It was previously used as an antipsychotic, although it is not generally administered for this purpose at present; promethazine has only about 1/10 of the antipsychotic strength of chlorpromazine.
Treatment of migraine; however, other similar drugs such as Compazine have been shown to have a more favorable treatment profile, and are used almost exclusively over promethazine.